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Recent years have seen significant improvement in chronic lymphocytic leukemia ( CLL ) management. Targeting B-cell lymphoma (BCL-2) and Bruton’s kinase (BTK) have become the main strategies ...
. The recommendations of the French Innovative Leukemia Organization (FILO- CLL ) group presented here are intended to provide practical recommendations for physicians taking care of CLL patients, taking into account ...
reached in the immunophenotypic and mutational status characterization of CLL . Hence, innovative therapeutics strategies are required together with the advancement in chemo-immunotherapy and targeted ...
decision-making, outlining best practices for venetoclax initiation and overall optimal treatment strategies in patients with CLL . ...
for both CLL and its microenvironment (e.g. macrophages), thus paving the way to an innovative therapeutic strategy . ...
SummaryChemoimmunotherapy (CIT) is defined as standard first line treatment for chronic lymphocytic leukemia ( CLL ) patients while patients with unfavorable biological characteristics ...
, and the development of next‐generation and immune‐based agents. Here, we review the recent advances in CLL therapy as well as the novel therapeutic innovations that are likely to contribute to the rapidly evolving ...
with the biological and clinical heterogeneity of CLL and offers opportunities for innovative treatment strategies . ARTICLE Received 29 Jun 2016 | Accepted 25 Apr 2017 | Published 9 Jun 2017 DOI: 10.1038/ncomms15746 ...
is known as Richter syndrome and represents a major unmet medical need because of treatment refractoriness, lack of targeted therapeutic strategies and unsatisfactory survival rates. Molecular investigations ...
, novel treatments efficiently directed toward specific CLL targets still lack and represent an urgent medical need. Recent compelling evidence suggests that CD5 abnormal expression is involved ...
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