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. The recipients received immunosuppression that included tacrolimus, sirolimus, corticosteroids, anti‐CD20 monoclonal antibody and TPC, an α‐galactosyl‐polyethylene glycol conjugate. In group 1 (n = 9) in addition ...
antibodies were found, indicating that the level of immunosuppression plays a major role. It is well-known that successful xenotolerance induction will need to rely on B and T cell tolerance [20,21 ...
1988 ; McCune and others 1988 ). In theory, eliminating the immune response to a xenograft should be sufficient to assure its success . This premise is of more than just theoretical importance ...
and leukotriens, culminating in intravascular thrombosis, interstitial haemorrhage and graft loss. It has long been recognised that hyperacute xenograft rejection is a major barrier to successful ...
, with the hope that at least one will prove successful . The broad paths to a cure may be considered either biological and surgical or mechanical. Biological and Surgical Approaches When successful , whole-organ ...
a success rate of 80% [6]. The difference between the second and the third group of patients may be due to the absence of immunosuppression in the case of the autotransplantation performed after total ...
and gliomas. Although recent successes of MB and GBM xenograft formation in mouse brains from freshly isolated cancer stem cells support their tumorigenicity [9], the rarity of cancer stem cells in primary ...
in the frequency of PTLD was first described in 1990 in heart transplant recipients, who received the monoclonal antibody against CD3 (OKT3, muromonab) in addition to standard immunosuppressive therapy [ 78 ...
. Crossref Search ADS PubMed WorldCat 115 Tze WJ , Tai J, Cheung SSC, Bissada N, Starzl TE. Prolongation of pig islet xenograft survival in rats by local immunosuppression with FK506 . Transplant Proc 1994 ...
establish cardiac transplantation as a successful procedure, risks of opportunistic infection and rejection, as well as coronary arteriopathy, have led to development of new immunosuppressive agents currently ...
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