HER-2 Positive and p53 Negative Breast Cancers are Associated With Poor Prognosis
Abstractp53 and HER-2 coexpression in breast cancer has been controversial. These markers were tested using immunohistochemistry and HercepTest. HER-2 expression is related to reduced breast cancer survival ( p == .02) . p53 expression relates to HER-2 expression ( p == .029). Coexpression between p53 and HER-2 has no relation to prognosis. On univariate and multivariate analysis, combination of HER-2 positive and p53 negative expression was associated with a poor prognosis ( p == .018 and p == .027, respectively), while the combination of HER-2 negative and p53 positive expression was associated with a favorable prognosis ( p == .022 and p == .010, respectively). Therefore the expression of these markers should be considered collectively.