Subscribe to thousands of academic journals for just $40/month
Read and share the articles you need for your research, all in one place.

Free radicals act as effectors in the growth inhibition and apoptosis of iron-treated Burkitt's lymphoma cells

Free Radical Research , Volume 40 (8) – Jan 1, 2006

Details

Publisher
Informa UK Ltd
Copyright
© 2006 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
Subject
Original
ISSN
1071-5762
eISSN
1029-2470
D.O.I.
10.1080/10715760500484344
Publisher site
See Article on Publisher Site

Preview Only

Expand Tray Hide Tray

Free radicals act as effectors in the growth inhibition and apoptosis of iron-treated Burkitt's lymphoma cells

Abstract

The addition of ferric citrate to Burkitt's lymphoma (BL) cell lines inhibits growth, leads to the accumulation of cells in the phase G 2 /M of the cell cycle and to the modulation of translocated c-myc expression. The increase in the labile iron pool (LIP) of iron-treated BL cells leads to cytotoxicity. Indeed, intracellular free iron catalyzes the formation of highly reactive compounds such as hydroxyl radicals and nitric oxide (NO) that damages macromolecular components of cells, eventually resulting in apoptosis. In this report, we have investigated the possible involvement of free radicals in the response of Ramos cells to iron. When added to Ramos cells, iron increased the intracellular levels of peroxide/peroxynitrite and NO. Moreover, the addition of free radicals scavengers (TROLOX ® and Carboxy-PTIO) neutralized the effects of iron on Ramos cells while addition of an NO donor or hydrogen peroxide (H 2 O 2 ) to cells generated effects which partially mimicked those induced by iron addition. Collectively, our results suggest the involvement of free radicals as effectors in the iron specific growth inhibition of BL cells observed in vitro .
Loading next page...

Preview Only. This article cannot be rented because we do not currently have permission from the publisher.

 
/lp/informa-healthcare/free-radicals-act-as-effectors-in-the-growth-inhibition-and-apoptosis-EcvKttbqKe