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if the sensitivity of SV40 transformed fibroblasts was caused by inactivation of p53 or some other alteration. Fibroblasts from Li - Fraumeni patients have only one functional p53 allele. Losing the active p53 allele ...
in fibroblasts ( 11 ). The relative resistance of p53 mutant HaCaT cells ( 48 ) supports observations made with p53 mutant fibroblasts from Li – Fraumeni patients ( 52 ). Primary p53 wild-type human fibroblasts ...
, have been proposed to originate from progenitor cells [19]. Mammary tumors from p53 heterozygous mouse models mimic Li - Fraumeni syndrome in women, and the tumors share gene expression patterns ...
treatment plan required 52–78 weeks to complete. Of the 14 patients evaluable for chemotherapeutic response (pre-RT), the objective response rate (CR + PR) was 62%. The objective response rate from radiation ...
investigated as to their genotoxin-induced chromosomal sensitivity. For fibroblasts obtained from Li – Fraumeni patients spontaneous genomic instability has been demonstrated resulting in aneuploidy ...
. However, in selected elderly AP patients with no other treatment options, low - dose amiodarone (50–200 mg/d) may offer angina control and improved quality of life. Dronedarone, its iodine-free methane ...
that initiate the progression of low -grade gliomas to more aggressive and deadly high-grade gliomas have not been well described. Lipocalin-type prostaglandin D2 synthase (PGDS) was identified from a microarray ...
. Genetic conditions that predict a higher risk for NRSTS include Li - Fraumeni syndrome [6], hereditary retinoblastoma [7], neurofibromatosis type I (malignant peripheral nerve sheath tumor [MPNST]) [8 ...
Scholar Ford,J.M. and Hanawalt,P.C. ( 1995) Li - Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV ...
-of-function mutations in this protein can lead to this subtype of lymphoma. Li – Fraumeni syndrome results from a loss in p53 function, consistent with the drastic predisposition to both rare and common neoplasms ...
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