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False positive urine drug screening for tricyclic antidepressants in patients taking quetiapine

False positive urine drug screening for tricyclic antidepressants in patients taking quetiapine

Abstract

Correspondence False positive urine drug screening for tricyclic antidepressants in patients taking quetiapine DOI: 10.3109/00048674.2011.580451 Saji Joseph Chathanchirayil, Goulburn Valley Area Mental Health Services, Shepparton, Victoria, Australia False positive urine drug screening (UDS) results can cause significant confusion for clinicians. Case reports have noted that people on quetiapine can exhibit false positive test results for tricyclic antidepressants (TCA) in assays of their urine or serum [1–3]. This report describes three patients who had false positive UDS results for TCA who were on quetiapine along with other different psychotropic medications. A 26 year old male with a diagnosis of treatment resistant paranoid schizophrenia and history of cannabis abuse, was on risperidone consta 62.5 mg intramuscularly every fortnight and quetiapine 600 mg oral per day. On a random UDS assay he showed positive for TCA on two occasions. He was not prescribed any TCA and he denies their use. A 43 year old woman with a diagnosis of paranoid schizophrenia and history of cannabis abuse was on flupenthixol decanoate 70 mg Intra-muscularly every fortnight, quetiapine 800 mg oral daily and diazepam on tapering dosage (ranges from 5 to 15 mg per day).On two occasions her UDS showed positive for TCA
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