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Effect of processing parameters on the properties of peptide-containing PLGA microspheres

Journal of Microencapsulation , Volume 14 (2) – Jan 1, 1997

Details

Publisher
Informa UK Ltd
Copyright
© 1997 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
Subject
Original Article
ISSN
0265-2048
eISSN
1464-5246
D.O.I.
10.3109/02652049709015330
Publisher site
See Article on Publisher Site

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Effect of processing parameters on the properties of peptide-containing PLGA microspheres

Abstract

The physico-chemical properties of biodegradable polylactide-co-glycolide (PLGA) microspheres containing the peptide salmon calcitonin (sCT) were affected by the processing parameters. The microsphere size increased with an increase in the viscosity of the polymer solution. Concentration of methanol and peptide in the dispersed phase had the most discernible effects with the combination causing external and internal porosity. Increasing sCT in the presence of methanol increased the surface area and porosity. The surface area also increased as the molecular weight of the polymer was decreased. At higher ratios of the dispersed phase volume to the continuous phase volume, the surface area and surface porosity were higher and the particle size was lower. Thus, the physico-chemical properties of the microspheres can be easily altered by varying the processing parameters allowing formation of microspheres with a range of properties. The microspheres may be used to evaluate the relationship between the properties and ultimate in-vivo performance.
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