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The effect of environmental acidity on the induction of apoptosis by heat was investigated. Human colorectal tumour RKO.C cells, carrying wild-type p53 and isogenic RC10.1 cells deficient in p53 ...
, induced a similar pattern of acidic p53 species as that observed for 2-MeOE2. The results indicated that the induction of apoptosis in H1299 cells by 2-MeOE2 is dependent on the upregulation of specific p53 ...
cells. On the basis of these observations, we suggest that ellagic acid induced cytotoxic effects for causing a decrease in the percentage of viable cells via G0/G1 phase arrest and induction of apoptosis ...
for the development of anticancer drugs. In the present study, it was investigated whether pre‑adaptation of malignant mesothelioma (MM) cells to an acidic environment was associated with a metabolic shift ...
exhibited inhibitory effect on HCC through induction of apoptosis and cell cycle arrest both in transplanted tumors and in HepG2 cells. OA induced apoptosis through mitochondrial pathway, evidenced ...
, pretreatment with vitamin C did not affect the p53 induction observed after chromium treatment. Neither vitamin had any effect on Cr-DNA adduct formation. These data indicate that although pretreatment ...
). Therefore, we investigated the effect of COX-2 induction on 2,2′,4,6,6′-PeCB-induced apoptosis using the selective COX-2 inhibitor, NS-398. Co-treatment with 2,2′,4,6,6′-PeCB and NS-398 further increased cell ...
, suggesting that functional p53 was required for the induction of apoptosis . At concentrations inducing apoptosis the three alkylpurines inhibited p70S6K activity, while they had the opposite effect on MAPK ...
on its previously described susceptibility to trichothecenes (Yang et al., 2000). The results indicate that DON induced the intrinsic pathway of apoptosis via phosphorylation of p38 and p53 . DON ...
. To investigate comparatively the role of c-Fos and p53 in the maintenance of genomic stability and the induction of apoptosis , we generated mouse fibroblast cell lines from knockout mice deficient for either c-fos ...
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