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to fusion inhibitors. Results Mutations that confer resistance to four fusion inhibitors, enfuvirtide , C34, SC34, and SC34EK, were introduced into the envelope of HIV-1JR-FL, a CCR5-tropic tier 2 strain ...
with drug- resistant HIV treated with enfuvirtide (ENF/T-20), an HIV-1 fusion inhibitor. Due to resistance emergence, ENF was removed from the drug regimen, drug-sensitive virus regrown, and ENF was re ...
concentrations in the genital tract may result in compartmentalized viral replication, selection of resistant mutations and possible re-entry of wild-type/ resistant virus into the systemic circulation. Therefore ...
study. Longitudinal studies addressing the dynamics of archived resistant quasi-species in cellular HIV DNA in heavily ART-experienced patients with controlled viraemia reported that most mutations ...
in very advanced disease with high viral loads because of the higher genetic barrier to resistance and slower rate of mutation selection seen with PIs, data to support PI- over NNRTI-based regimens ...
of antiretroviral schemes is related to the number of resistance mutations in the HIV-1 PR (α = 0.2511, P = 0.0003, R2 = 0.8672) and the RT (α = 0.7892, P = 0.0001, R2 = 0.9141). Increased informational entropy rate ...
Dynamics of resistance to one, two and three or more antiretroviral classes were evaluated from 1999–2018. Virological success (VS) after the latest therapy switch was evaluated according to cumulative class ...
gp120 sequences from the Los Alamos HIV Database were analysed for mutation prevalence at fostemsavir resistance -associated positions and potential association with other gp120 polymorphisms. The role ...
when HIV treatment- resistant patients received standard doses of darunavir, ritonavir, etravirine, raltegravir, and nucleoside analogs with or without enfuvirtide . Debate exists regarding the best ...
, emtricitabine; MVC, maraviroc; RAL, raltegravir; T20, enfuvirtide ; TDF, tenofovir disoproxil fumarate. Mutations in bold: mutations detected only by UDS. Table 4. Prevalence of resistant variants at baseline ...
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