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criteria for receptor-mediated diagnostic imaging. Its [ 125 ] I - labeled sister nuclide derivative [125I]E decays by orbital electron capture with emission of very-low-energy (Auger) electrons, which gives ...
-based assays. We show here that cytotoxic activity of TWJ-/G4- ligands is mitigated by the DNA damage response (DDR) and DNA topoisomerase 2 (TOP2), making them different from typical G4- ligands ...
cells than their respective ligand counterparts. The cytotoxicity of the series of salicylaldehyde semicarbazone derivatives and their corresponding Cu(ii) complexes, as well as cisplatin, against ...
KCl or NaCl. This enzyme could be involved in the replication of ctDNA. The DNA major groove-intercalating ligands nogalamycin and daunorubicin were inhibitory to unwinding (K i approximately 0.85 μm ...
ABSTRACT Acridine-4-carboxamides form a class of known DNA mono-intercalating agents that exhibit cytotoxic activity against tumour cell lines due to their ability to inhibit topoisomerases. Previous ...
Abstract T cell-mediated cytotoxicity can be triggered by cross-linking of TCR or Thy-1 surface proteins. While the TCR-triggered signaling initiates both perforin- and Fas ligand (FasL)–Fas-mediated ...
Abstract Human DNA ligase I (LIG1) is the main replicative ligase and it also seals DNA breaks to complete DNA repair and recombination pathways. Immune compromised patients harbor hypomorphic LIG1 ...
expression of classical MHC class I molecules (U266 62%, RPMI-8226 99·7%, OPM-2 97·6%), suggesting that natural cytotoxicity against these cell lines is unlikely. Regarding NKG2D ligands , mRNA of MICB could ...
), ds DNA (60±1) °C; maximum measurable Tm = 93 °C. Dual FAM-TAMRA labeled sequences were used in the FRET melting experiments. bΔTm at 1 μM ligand concentration [°C] (ΔTm = ± 1°C). cKd = ± 10% (expressed ...
μL Dimethyl sulfoxide (DMSO) and added to 0.75 ml of 0.01 mM protein solution (20-fold molar excess of MTSSL). The protein solution was then vortexed overnight at 4°C. The free spin label and Cu( I ...
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