Cryptococcus gattii : in vitro susceptibility to the new antifungal albaconazole versus fluconazole and voriconazole
AbstractMinimal inhibitory concentrations (MIC) and minimal fungicidal activity of albaconazole, voriconazole and fluconazole against 55 strains of Cryptococcus gattii , clinically or environmentally isolated in Spain and some Latin American countries, were assessed. By means of the microbroth method (National Committee for Clinical Laboratory Standards; document M27-A2), the geometric mean value for fluconazole was 5.01 µg/ml; however, MIC for 12.7% of isolates ranged from 16 to 32 µg/ml, suggesting increased resistance against fluconazole. Geometric mean values of 0.02 and 0.03 µg/ml for albaconazole and voriconazole, respectively, were found, indicating not only a higher susceptibility to these new azoles but also a better performance of albaconazole ( P = 0.003). Minimal fungicidal concentrations were also very low for albaconazole and voriconazole ( P <0.001; geometric mean values of 0.023 µg/ml and 0.07 µg/ml, respectively). Both azoles may be good alternatives for the treatment of C. gattii cryptococcosis.