Correspondence and Short Communications: Dissolution Time for Three Formulations of Cyclophosphamide Powder for Injection
Abstract
CORRESPONDENCE Act11 Oncologica Vol. 30 No. 7 1991 Correspondence ,and Short Communications Comments on puhli.shed articles. short communications of a preliminary nature, cuse reports. technical notes and the like are accepted under this heading. The articles should be short and concise and contain a minimum of jigures. tables and references. 1 DISSOLUTION TIME FOR THREE FORMULATIONS OF CYCLOPHOSPHAMIDE POWDER FOR INJECTION Many formulations of cyclophosphamide for parenteral use are inconvenient to use, due to the prolonged time required for their dissolution ( I ). The new lyophilized form of cyclophosphamide has been reported to be easier to prepare than the conventional form of the drug, an advantage which reduces the time needed to prepare the drug for injection (Kjrer & Bjeldbak; unpublished report). The present study was undertaken with the aim of comparing the dissolution time for three preparations of cyclophosphamide available in the Nordic countries. Esperimentul. Endoxan ( lyophilized cyclophosphamide) (200 mg (Batch No. 88937). 500 mg (Batch No. 08901 ), I OOO mg (Batch No. 88948)) and Sendoxan (200 mg (Batch No. 029047), 500 mg (Batch No. 098887). 1 000 mg (Batch No. 108774)) were obtained from AP Medical AB. Tiby, Sweden. Cyklofosfamid (200 mg (Batch