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(NO) production, we hypothesized that PTEN contributes to TNF‑ α‑ mediated vascular resistance to insulin induced by HFD. Mechanisms underlying PTEN effects were determined. Methods: Mesenteric vascular beds were ...
Summary Aims The aim of the study was to analyse the role of tumour necrosis factor‐alpha (TNF‐α) in insulin resistance and endothelial dysfunction in patients with different types of obesity ...
of inflammation with obesity and insulin resistance on vascular function, and also details the role of perivascular adipose tissue in contributing to vascular dysfunction . The final review extends this general ...
and clinical data that support the contribution of abnormal MR activation to the development of vascular insulin resistance and dysfunction . International Journal of Molecular Sciences Review Mineralocorticoid ...
? Endothelial Mitochondria: Contributing to Vascular Function and Disease Marshall S. Runge, Guest Editor Jeong-a Kim, Yongzhong Wei, James R. Sowers Abstract— Insulin resistance is characteristic of obesity, type ...
cytokines are systemic disturbances in individuals with obesity, T2DM, and insulin resistance and each of these contribute independently and synergistically to decreasing NO bioavailability. This review ...
wall (arterial stiffness), vascular calcification, and increased thickness of the arterial wall. Vascular dysfunction associated to insulin resistance is present in asymptomatic subjects and predisposes ...
, and brain insulin resistance . Identification of molecular mechanisms perpetrating this pathological cascade is critical for elucidating vascular contributions to Alzheimer's disease.MethodsTo capture rapid ...
Abstract— Insulin resistance in the vasculature is a characteristic feature of obesity and contributes to the pathogenesis of vascular dysfunction and disease. However, the molecular mechanisms underlying ...
intracellular signaling pathways. Under insulin - resistant conditions, increased insulin concentrations and/or impaired insulin -signaling pathways in the vasculature may contribute to imbalance in secretion ...
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