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and SEM); phase - solubility diagrams and 1H-NMR experiments revealed a strong association constant. Complexation with HP-β-CD not only improved OXZ solubility but also delayed in vitro release of OXZ ...
, which could be defined as classic AL-type phase - solubility diagrams, leading to the formation of dissolved inclusion complex in 1 : 1 ratio of BCL/β-CD stoichiometry, in agreement with the previous ...
of β-CD with propylene oxide, resulting in an isomeric system that has an aqueous solubility well in excess of 60% (w/v; Pitha et al., 1987). To be active, the drug included in the CD must be released ...
straight line of the phase solubility plot [Eq. 1]. It was markedly higher (5.6 per mm) for pH 7 than for pH 5 (0.155 per mm) and pH 3 (0.065 per mm), indicating much greater formation of inclusion complex ...
drug release studies In- vitro drug dissolution profiles for CX, physical mixtures and melt extrudates (pre and post scCO2 exposure), either as formed tablets or milled samples, were examined using ...
drug release percentage. The whole process was carried out at room temperature. Microsphere characterization Particle size Particle size of the AZI microspheres was determined by an AccuSizer780/DPS dry ...
the CAPA® 6506 core of the co-extruded dosage form. Inclusion of Kollidon® VA 64 in the coat ensured complete release over 24 h of gliclazide via solubilization of the drug in the Kollidon® VA 64 phase ...
Abstract Objective The aim of this study was to investigate Pluronic F127-modified liposome-containing cyclodextrin (CD) inclusion complex (FLIC) for improving the solubility , cellular uptake ...
in ethanol to be 11.4 ± 0.33 mg/ml.[16,24] These solubilities dictate the extent of drug diffusion to the surface of the microparticles during the preparation process and ultimately affect drug release ...
, in addition to DSC and SEM, other techniques such as the phase solubility study, power X-ray diffractometry, nuclear magnetic resonance, Fourier-transform infrared spectroscopy, in vitro release and others ...
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