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models in comparison to the existing in vitro and in vivo exposure system for testing air pollutants mediated pulmonary toxicity . air-liquid interface, air pollution, pulmonary toxicity Series ...
of HepG2 and AML12, and could be a promising in vitro model for the study of MC-LR cellular toxicity mechanisms.33 Later, Alverca et al. (2009) also found that Vero-E6 cellular response to MC-LR exposure ...
) ≤ 11 h 0.842 SBA15-cal 0.27 ± 0.06 (n = 5) ≤12 h 0.907 Cellular mitochondrial oxygen consumption (μM O2/min/mg) Duration of incubation p Value Untreated 0.27 ± 0.03 (n = 4) MCM41-cal 0.26 ± 0.06 (n = 4 ...
to represent pulmonary fibrosis and were further explored for information associated with the disease. The online interaction prediction software GeneMANIA (Warde-Farley et al. 2010) was used to identify genetic ...
modifying the C60 itself ( 11 ). Although these dispersion techniques are excellent for industrial purposes, it is unclear whether the technique is suitable for in vitro toxicity assessment. For example, Tween ...
in NM properties can alter subsequent behavior and cellular interactions . Although nanotoxicology has seen some revolutionary accomplishments, certain critical areas require attention and key challenges ...
attachment were unable to recreate the cell–extra cellular matrix (ECM) interaction in vivo. In this study, we developed a biomimetic 3D lung-on-a-chip to provide pulmonary toxicity assays of nanoparticles ...
respiration may also attenuate cellular hypoxic stress ( 11 ), by the downregulation of PGC-1α-dependent genes and enhanced membranal cholesterol content. ROS and HIF interactions (12) are complex and to some ...
) with target cells (alveolar epithelial cells, AEC; rat pulmonary artery endothelial cells, RPAEC). The goal of this study was to elucidate hypoxia-induced changes of effector–target cell interaction . AEC ...
. Effective treatment of paraquat poisoning is lacking although nowadays paraquat is known as a classical example of a pulmonary redox-active toxicant . After being taken up by cells, e.g. pneumocytes, paraquat ...
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