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Downloaded from http://journals.lww.com/drug-monitoring by BhDMf5ePHKbH4TTImqenVJ2toCr/9wZZjwPUWvYES9l2nY+zyylnl33NGMK6MRsx on 10/01/2020 CASE REPORT Neurotoxicity Despite a Renal Function- Adjusted ...
. Consequently, the man’s cefepime therapy dose was reduced by eight times [outcome not stated]. Engalenc X, et al. Neurotoxicity Despite a Renal Function- Adjusted Cefepime Regimen: A Case Study. Therapeutic Drug ...
Despite PATIENT PRESENTATION Dose Adjustment for Renal Our patient was an 18-year-old boy with a history of very-high- risk pre-B-cell acute lymphoblastic leukemia in his second com- Disease: A Brief Report ...
was renally dose adjusted . These patients may benefit from TDM. TDM allowed for confirmation of interventions and further interventions were made based on trough levels. Despite a small sample size, cefepime ...
] and underlying neurological disease. Antibiotic dose adjustments in renal dysfunction and culprit drug discontinuation are key [3]. A high index of suspicion is warranted to diagnose antibiotic-induced ...
to neurotoxicity with the use of cefepime IVP. The neurotoxicity characterized in these elderly patients included altered mental status and myoclonic jerking. Three of these patients had appropriate renal dose ...
announcement was issued by the FDA in 2012 underlining the need for cefepime dose adjustment in patients with renal impairment to avoid neurotoxicity .26 However, at appropriate dosing (with renal adjustment ...
. Vancomycin + cefepime therapy was independently associated with reduced microbiologic failure ( adjusted odds ratio [aOR], 0.488; 95% confidence interval [CI], 0.271–0.741). This was driven by a reduction ...
as an overexposure. Piperacillin/tazobactam and cefepime were prescribed at the dose of 4 g/0.5 g and 2 g q8h, respectively. Antimicrobials were not administered simultaneously. Of note, metronidazole was additionally ...
’ clinical condition (including body size, haemodynamic status, renal and hepatic function) and known or likely pathogen. Loading doses were given when continuous infusion was used. Subsequent dose adjustment ...
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