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of these classes, ethyl β- carboline - 3 - carboxylate (β-CCE), was obtained from human urine by virtue of its high affinity for benzodiazepine receptors. It was hypothesized that derivatives or congeners of this β ...
- carboline - 3 - carboxylic acid derivative might, in part, be the endogenous ligand for the brain benzodiazepine receptor. We have examined several synthetically derived β- carboline - 3 - carboxylic acid analogues ...
A. T. Dolzhenko, V. I. Dulenko, UDC 615.214.22.076.9 L. Ya. Zin'kovskaya, and I. V. Komissarev There have been recent reports of the higb activity of ~- carboline - 3 - carboxylic acid [1], harman (I ...
Abstract: The effects of two anxiolytic β‐ carboline derivatives , ZK 93423 and ZK 91296, on the binding of γ‐(3H)aminobutyric acid ((3H)GABA) to brain membrane preparations from rat cerebral cortex ...
that benzodiazepine and β‐ carboline binding sites represent different recognition sites. Abbreviations. ECC ethyl β‐ carboline ‐ 3 ‐ carboxylate FNP flunitrazepam GABA γ‐aminobutyric acid HEPES N ‐2‐hydroxyethylpiperazine ...
- carboxylic acid [9, i0], interact with high affinity with the specific binding sites of benzodiazepine tranquilizers (BD) in membrane fragments of the brain . These ligands of the benzodiazepine receptors ...
. Abbreviations used: 2‐APH 2‐amino‐7‐phosphonoheptanoic acid β‐CCE β‐ carboline ‐ 3 ‐ carboxylate β‐CCM β‐methyl‐β‐ carboline ‐ 3 ‐ carboxylate DMCM methyl‐6,7‐dimethoxy‐4‐ethyl‐β‐ carboline ‐ 3 ‐ carboxylate GABA γ‐aminobutyric ...
. In contrast, the inhibitory effects of the benzodiazepine receptor inverse agonists FG 7142 (10 µM) and 6,7‐dimethoxy‐4‐ethyl‐β‐ carboline ‐ 3 ‐ carboxylic acid ethyl ester (1 µM) were reduced by 48 and 38 ...
‐ethyl‐ β ‐ carboline ‐ 3 ‐ carboxylate TBPS t ‐butylbicyclophosphorothionate Introduction GABA A ( γ ‐aminobutyric acid type A) receptors, the principal mediators of fast synaptic GABAergic inhibitory ...
, Braestrup C: [3H] Proply- carboline - 3 - carboxylate binds specifically to brain benzodiazepine receptors . J Neurochem 1981;36:276-285.Crossref 45. Marangos PJ, Patel J, Hirata F, et al: Inhibition of diazepam ...
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