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Calcitonin effects on rabbit bone

Acta Orthopaedica , Volume 63 (6) – Jan 1, 1992

Details

Publisher
Informa UK Ltd
Copyright
© 1992 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
Subject
Original Article
ISSN
1745-3674
eISSN
1745-3682
D.O.I.
10.1080/17453679209169720
Publisher site
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Calcitonin effects on rabbit bone

Abstract

30 adult male New Zealand white rabbits underwent osteotomy and plate fixation of the left ulna for 6 or 12 weeks. The right ulna served as control. In half of the rabbits 6 IU calcitonin was given daily until death, and in the other half placebo injections in the same manner. A three-point bending test was performed on both ulnae. Sections of bone, covered or uncovered by the plates, were examined histologically. Long-term administration of calcitonin increased the mechanical properties of both fractured and intact bones and reduced porosity of the cortex under the plate.
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