Subscribe to thousands of academic journals for just $40/month
Read and share the articles you need for your research, all in one place.

Blood Monocyte Elastolytic Activity Enhanced by Immune Complex Stimulation in Patients with Rheumatoid Arthritis and Normal Controls Effect ofAurothiomalate or D-penicillamine

Details

Publisher
Informa UK Ltd
Copyright
© 1989 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted
Subject
Original Article
ISSN
0300-9742
eISSN
1502-7732
D.O.I.
10.3109/03009748909095033
Publisher site
See Article on Publisher Site

Preview Only

Expand Tray Hide Tray

Blood Monocyte Elastolytic Activity Enhanced by Immune Complex Stimulation in Patients with Rheumatoid Arthritis and Normal Controls Effect ofAurothiomalate or D-penicillamine

Abstract

Blood monocyte elastolytic activity in patients with rheumatoid arthritis and in normal controls was studied by a new in vitro technique. The enzyme activity of live cells was measured by soluble ( 3 H)elastin hydrolysis first under basic conditions and then after immune complex stimulation. The cells from patients had a higher elastolytic potential than cells from controls ( p <0.02) and responded to smaller amounts of immune complex ( p <0.01), even in patients treated with D-penicillamine or aurothiomalate. Treatment of normal monocytes in vitro with aurothiomalate did not influence the elastolytic response. These findings indicate that monocytes from patients with rheumatoid arthritis have an enhanced elastolytic activity compared with cells from normal controls and may invoke greater tissue damage on immune complex stimulation.
Loading next page...

Preview Only. This article cannot be rented because we do not currently have permission from the publisher.

 
/lp/informa-healthcare/blood-monocyte-elastolytic-activity-enhanced-by-immune-complex-S8zT5IUJdq