“Woah! It's like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $40/month

Get 2 Weeks Free

Blood Monocyte Elastolytic Activity Enhanced by Immune Complex Stimulation in Patients with Rheumatoid Arthritis and Normal Controls Effect ofAurothiomalate or D-penicillamine

Blood Monocyte Elastolytic Activity Enhanced by Immune Complex Stimulation in Patients with Rheumatoid Arthritis and Normal Controls Effect ofAurothiomalate or D-penicillamine

Abstract

Blood monocyte elastolytic activity in patients with rheumatoid arthritis and in normal controls was studied by a new in vitro technique. The enzyme activity of live cells was measured by soluble ( 3 H)elastin hydrolysis first under basic conditions and then after immune complex stimulation. The cells from patients had a higher elastolytic potential than cells from controls ( p <0.02) and responded to smaller amounts of immune complex ( p <0.01), even in patients treated with D-penicillamine or aurothiomalate. Treatment of normal monocytes in vitro with aurothiomalate did not influence the elastolytic response. These findings indicate that monocytes from patients with rheumatoid arthritis have an enhanced elastolytic activity compared with cells from normal controls and may invoke greater tissue damage on immune complex stimulation.
Loading next page...
Problems Reading this Article? Report Issue Here
 
/lp/informa-healthcare/blood-monocyte-elastolytic-activity-enhanced-by-immune-complex-S8zT5IUJdq

You're reading a free preview. Subscribe to read or print the entire article.

And millions more from thousands of peer-reviewed journals, for just $40/month.

Get 2 Weeks Free

To be the best researcher, you need access to the best research

  • With DeepDyve, you can stop worrying about how much articles cost, or if it's too much hassle to order — it's all at your fingertips. Your research is important and deserves the top content.
  • Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.

Stop missing out on the latest updates in your field

  • We’ll send you automatic email updates on the keywords and journals you tell us are most important to you.
  • There is a lot of content out there, so we help you sift through it and stay organized.