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, 2009 Copyright © Informa UK Ltd. ISSN: 0886-022X print / 1525-6049 online DOI: 10.3109/08860220903150312 LRNF CLINICAL STUDY Antifibrotic Effects of Aldosterone Receptor Blocker ( Spironolactone ...
the effect of aldosterone and spironolactone , which is a non‐selective mineralocorticoid receptor antagonist, on monocyte chemoattractant peptide (MCP‐1) and collagen synthesis in cultured mesangial ...
-β) called endothelial-to-mesenchymal transition (EndMT). We investigated whether the aldosterone receptor - blocker spironolactone could abrogate TGF-β-induced fibrosis in EndMT and the underlying ...
and clinical studies showing antifibrotic and cardioprotective effect for aldosterone antagonists, spironolactone and eplerenone. In chronic heart failure and post myocardial infarction patients, aldosterone ...
PubMed 53 Guney I, Selcuk NY, Altintepe L, et al. Antifibrotic effects of aldosterone receptor blocker ( spironolactone ) in patients with chronic kidney disease, Ren Fail , 2009, vol. 31 (pg. 779 ...
for the treatment of primary hypertension for >70 years.1 Their use was originally based upon the effect of spironolactone on blocking the effects of aldosterone on the renal absorption of sodium and excretion ...
/mL/h with high plasma aldosterone (≥440 pmol/L) and ARR ≥830 for patients off angiotensin-converting enzyme inhibitor (ACEi) or angiotensin receptor blocker (ARB); or PRA ≤1 ng/mL/h and ARR ≥830 ...
. Limitations of non-selective aldosterone receptor blockade Although spironolactone is an effective anti- aldosterone agent, its widespread use in humans is limited by its tendency to produce undesirable sexual ...
, however, 10 μmol/L aldosterone was used. At this dosage aldosterone acts on the glucocorticoid receptor , which is confirmed by the fact that the effect was reversed by 50% by equimolar spironolactone ...
slide Plasma levels of NE (A), ET-1 (B), aldosterone (AL; C), and proANP (D) in DR, DS, DS + SP, and DS + P rats after 40 d of an 8% NaCl diet. n.s., Not significant. Effects of spironolactone on cardiac ...
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