“Woah! It's like Spotify but for academic articles.”

Instant Access to Thousands of Journals for just $40/month

Get 2 Weeks Free

Anti-Tumor Effect of Mitoxantrone-Loaded Bovine Casein Microspheres on Ehrlich Ascites Carcinoma in Mice

Anti-Tumor Effect of Mitoxantrone-Loaded Bovine Casein Microspheres on Ehrlich Ascites Carcinoma in Mice

Abstract

This work was supported with a grant SP/SO/D-21/89 from the Department of Science and Technology, Government of India. A. J. thanks the Director, TBG&RI for collaboration and Prof. E. P. Goldberg of the University of Florida, USA for a generous gift of mitoxantrone. Glutaraldehyde cross-linked bovine casein microspheres loaded with the antineoplastic agent mitoxantrone were prepared and in vitro release of the drug into phosphate buffer was examined at 37°C. In the absence of any proteolytic enzymes, the release reached a steady state within a week, releasing only 17–40% of the incorporated drug, depending on the initial payload. In the presence of an enzyme such as protease, however, 100% release was seen in vitro in 2–3 days. The antitumor effect of mitoxantroneloaded microspheres was evaluated in Swiss albino mice bearing Ehrlich ascites carcinoma (EAC) by intraperitoneal injections. The mean survival time of mice receiving 1 mg of mitoxantrone as free drug was 4.6 ± 0.67 days as opposed 37.7 ± 2.9 days for mice receiving equivalent amount of drug encapsulated in microspheres ( p <. 001). The percent T/C ratio of the animals receiving treatment via microsphere modality was 219.2, as opposed to 26.7 for the group receiving therapy using free drug. There was no significant increase in the body weight of animals receiving the drug-loaded microspheres. It is demonstrated that sustained delivery of mitoxantrone intraperitoneally using casein microspheres would be a promising approach in the treatment of EAC
Loading next page...
Problems Reading this Article? Report Issue Here
 
/lp/informa-healthcare/anti-tumor-effect-of-mitoxantrone-loaded-bovine-casein-microspheres-on-q3NjaooYCN

You're reading a free preview. Subscribe to read the entire article.

And millions more from thousands of peer-reviewed journals, for only $40/month.

Get 2 Weeks Free

To be the best researcher, you need access to the best research

  • With DeepDyve, you can stop worrying about how much articles cost, or if it's too much hassle to order — it's all at your fingertips. Your research is important and deserves the top content.
  • Read from thousands of the leading scholarly journals from Springer, Elsevier, Nature, IEEE, Wiley-Blackwell and more.
  • All the latest content is available, no embargo periods.

Stop missing out on the latest updates in your field

  • We’ll send you automatic email updates on the keywords and journals you tell us are most important to you.
  • There is a lot of content out there, so we help you sift through it and stay organized.