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In this manuscript we have characterized the androgen receptor from human benign prostatic hypertrophied (BPH) tissue. BPH tissue was obtained fresh from surgery, ground, and frozen in liquid ...
The synthetic steroid methyltrienolone (R1881, 17β-hydroxy-17α-methyl-estra-4,9,11-trien-3-one) binds with high affinity to protein in cytosols prepared from human hyperplastic prostate . R1881 also ...
claf, Romainville K e y Words. M ethyltrien olone • Androgen receptors • Progesterone binding Abstract. The binding o f m ethyltrienolone (R 1881) in crude human hyperplastic prostate cytosol ...
Abstract Direct measurement of the binding of endogenous androgens to the androgen receptor of human tissues has not been possible because of contamination of tissue with traces of plasma proteins ...
, Houston, TX 77030 The androgen receptor from human benign prostatic hypertrophied (BPH) tisue was characterized with respect to its physicochemical and DNA- binding properties. Tissue was homogenized in 10 ...
in the tissue from treated patients positive staining was found also in the glandular epithelium. These results demonstrate that: 1) specific binding sites for IGF-I are present in prostatic tissue from patients ...
dephosphorylated, displaces Bax from binding to Bcl-2 and Bcl-XL, resulting in cell death (107). Bad phosphorylation frees Bcl-2 and Bcl-XL, allowing them to act as antiapoptotic proteins . In the normal prostate ...
-independence in human prostate cancer cells and its growth. (A) protein levels of TOPK, androgen receptor (FL-AR at 110 kDa, AR variants at 80 kDa), and the AR alternatively spliced variant (ARv7; 80 kDa ...
refractory prostate cancer (HRPC) is becoming a more widely accepted term. The most prominent player in the progression of AIPC is the androgen receptor (AR), a protein that binds to androgens and acts ...
be unable to bind androgen but remain constitutively activated, or they may bind androgen but be nonfunctional (15)(25). AR mutations in prostate cancers are commonly point mutations but may also reflect ...
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