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with thrombospondin motif (ADAMTS)-4 and ADAMTS-5, which was reflected by markedly decreased degradation of aggrecan . Inhibition of DPP-4 by saxagliptin also reduced oxidative stress in human primary chondrocytes ...
During the progression of osteoarthritis, dysregulation of extracellular matrix (ECM) anabolism, abnormal generation of reactive oxygen species, and proteolytic enzymes have been shown to accelerate ...
with thrombospondin motifs‐5 (ADAMTS5) expression and the reduction of collagen type IIα (Col2a1) and Aggrecan expression in interleukin‐1 β (IL‐1β) induced chondrocytes . The animal experiments proved that depleting ...
, a scavenger of reactive oxygen species, on chondrocyte metabolism Received: February 26, 2003 / Accepted: June 17, 2003 Abstract Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)- Ebselen (2-phenyl-1,2 ...
, which mediate reactive oxygen species pathology in chondrocytes . At the clinical level, ASU reduces pain and stiffness while improving joint function, resulting in decreased dependence on analgesics ...
, Win-55,212–2, to determine if the effects were cannabinoid (CB)-receptor mediated . The chondrocytes and explants were stimulated by IL-1α (100 U mL−1 ≡ 0.06 nm and 500 U mL−1 ≡ 0.3 nm, respectively ...
of reactive oxygen species in homeostasis and degradation of cartilage . Osteoarthr Cartil . 2003 ; 11 : 747 – 755 . Google Scholar Crossref Search ADS WorldCat Pelletier JP , Jovanovic D, Fernandes JC, Manning ...
, chondrocytes can lose their native phenotype and dedifferentiate. This phenotypic instability, which results in cessation of type II collagen and aggrecan production, has been demonstrated for many animal ...
expressed by chondrocytes is the main enzyme responsible for ROS formation, contributing to increased oxidative stress inside the joint and mediating the cartilage collagen degradation , structural ...
by macrophages leads to lysosomal rupture, reactive oxygen species production, ATP release, potassium efflux and NLRP3-dependent IL-1 processing and secretion [6, 7]. CPP crystals have also been shown to drive ...
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