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considered drug related due to an increased incidence of gallbladder mucosal hyperplasia at these doses . There was a dose - related increased incidence of transitional cell papilloma and carcinoma of the urinary ...
of anti-recombinant GH antibodies. The high doses selected for the carcinogenicity studies provided systemic exposures of GH up to approximately 10-fold over basal levels. In the 105-week mouse ...
substantially increase the numbers of persons exposed to tobacco smoke carcinogens . If this occurs, tobacco- related disease may increase in our society, even if some reduction is achieved for individual smokers ...
. not IARC class 1 carcinogens ). We also looked for chemicals that may potentially target the genes/pathways related to an immune evasion hallmark of cancer (Table 1). The objective of this review ...
., 1999; So and Winder, 1972; Williams et al., 1981), an aromatic amine carcinogen related to PhIP. Thus, we utilized Syrian hamsters, congenic at the NAT2 locus, to investigate the specific role ...
, 95% CI = 0.3% to 4.9%; P = 1.00, .85, .17 comparing the two-dose0/6, two-dose0/1, and one- dose groups to the three- dose group, respectively). The prevalence of other carcinogenic and noncarcinogenic ...
bioassay has evolved into the primary means to determine the carcinogenic potential of a chemical and generate quantitative information on the dose -response behavior for chemical risk assessments ...
in the case of certain groups (e.g., children) who would be expected to have both more exposure and greater age - related susceptibility to certain carcinogens . Scientists and policy makers now widely agree ...
of the Maximum Permissible Concentration. And it warned that the amounts of Sr - 90 in human bones might reach this ‘warning dose ’ in the proceeding decades (Medical Research Council, 1956). Why did the BEAR and MRC ...
Abstract Cytochrome b5 (b5) and NADH cytochrome b5 reductase (b5R) detoxify reactive hydroxylamine (NHOH) metabolites of known arylamine and heterocyclic amine mammary carcinogens . The aim ...
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