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AbstractObjective. Our study aimed to investigate the relationship between exercise - induced pulmonary arterial hypertension and genetic changes related to the transforming growth factor-β (TGF-β ...
, is pulmonary hypertension also associated with other types of predispositions to hemolysis? For example, mutations in the G6PD gene that leads to decreased activity of the protein in erythrocytes can induce ...
) gene .26,27 The BMPR2 receptor is a member of the transforming growth factor β (TGF-β) superfamily, and mutations have been shown to result in a disturbed TGF-β/BMP balance. Also less common genetic ...
cardiovascular disorders [7–11]. Mutations in this gene might also lead to diffuse developmental disorders in the lungs in neonates [12, 13]. Pulmonary Venooclusive Disease (PVOD) is the most lethal subtype of PAH ...
pulmonary blood flow, toxins, and drugs (e.g. monocrotaline, bleomycin), or gene targeting, shares certain characteristics with the human disease (Table 1). Whereas large animal models allow a better ...
aspartate aminotransferase APAH associated pulmonary arterial hypertension BAS balloon atrial septostomy BMPR2 bone morphogenetic protein receptor 2 BNP brain natriuretic peptide BPA balloon pulmonary ...
and reduced penetrance of familial PAH (only 20% of BMPR2 gene mutation carriers manifest the disease), suggests that additional triggers are required for the development of the condition. Mechanisms could ...
of administration of the recommended test compounds for vasoreactivity testing in pulmonary arterial hypertension 30 Table 13 Phenotypic features associated with pulmonary arterial hypertension mutations 32 Table ...
JA 3rd . , Palomero T , Sumazin P , Kim HR , Talati MH , West J , Loyd JE , Chung WK . Whole exome sequencing to identify a novel gene (caveolin-1) associated with human pulmonary arterial hypertension ...
of underlying distinct mechanisms and help utilize novel targets or biomarkers to develop treatments for patients suffering from right heart diseases. MicroRNAs, Right ventricular remodelling, Pulmonary ...
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