Up-regulation of CD36/FAT in preadipocytes in familial combined hyperlipidemia Steven J. R. Meex * ,1 , 2 , Carla J. H. van der Kallen * , 2 , Marleen M. J. van Greevenbroek * , Petra M. H. Eurlings * , Mohammed El Hasnaoui * , Chris T. A. Evelo † , Patrick J. Lindsey ‡ , Joost J. F. P. Luiken § , Jan F. C. Glatz § and Tjerk W. A. de Bruin * * Laboratory of Molecular Metabolism and Endocrinology, Department of Internal Medicine, † BiGCaT Bioinformatics, ‡ Department of Human Genetics, and § Department of Molecular Genetics, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, The Netherlands 1 Correspondence: Department of Internal Medicine, Laboratory of Molecular Metabolism and Endocrinology, Maastricht University, P.O. Box 616, Maastricht 6200 MD, The Netherlands. E-mail: steven.meex@intmed.unimaas.nl <h3>SPECIFIC AIMS</h3> The aim of our study was to identify primary genetic alterations, or the direct cellular consequences thereof, in adipose tissue from patients with familial combined hyperlipidemia (FCHL), a genetic dyslipidemia with typical features of the metabolic syndrome. Gene expression experiments in cultured human preadipocytes from FCHL subjects and controls allowed us to suppress expression differences due to metabolic influences, whereas primary
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Up-regulation of CD36/FAT in preadipocytes in familial combined hyperlipidemia
Meex, Steven J. R.; van der Kallen, Carla J. H.; van Greevenbroek, Marleen M. J.; Eurlings, Petra M. H.; El Hasnaoui, Mohammed; Evelo, Chris T. A.; Lindsey, Patrick J.; Luiken, Joost J. F. P.; Glatz, Jan F. C.; de Bruin, Tjerk W. A.
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, Volume 19 (14): 2063
Fed of American Socs for Experimental Biology – Dec 1, 2005
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