Uncomplicated human obesity is associated with a specific cardiac transcriptome: involvement of the Wnt pathway PIERRE PHILIP-COUDERC * , ATUL PATHAK * , FATIMA SMIH * , CAMILLE DAMBRIN † , ROMAIN HARMANCEY * , SOPHIE BUYS * , MICHEL GALINIER * ,‡ , PIERRE MASSABUAU * ,‡ , JEROME RONCALLI * ,‡ , JEAN-MICHEL SENARD * and PHILIPPE ROUET * * Unité de recherches sur les obésités, Institut National de la Santé et de la Recherche Médicale (Inserm U586), Institut Louis Bugnard, Centre Hospitalier Universitaire de Toulouse, Université Paul Sabatier, Toulouse, France; and † Department of Cardiovascular Surgery and ‡ Department of Cardiology, Toulouse University Hospital, Toulouse, France 1 Correspondence: INSERM U586, Faculté de Médecine, Laboratoire de Pharmacologie Médicale et Clinique, 37 Allées Jules Guesde. 31073 Toulouse cedex, France. E-mail: Philippe.rouet@toulouse.inserm.fr A dramatic increase in the prevalence of obesity and cardiovascular morbidity is expected in the coming years for most countries. However, little is known about the specific contribution of obesity to (associated) cardiovascular morbidity. Molecular mechanisms of heart adaptation to obesity so far have not been investigated. <h3>SPECIFIC AIMS</h3> We aimed to define the specific cardiac alterations detectable at the molecular level in the obese human
/lp/fed-of-american-socs-for-experimental-biology/uncomplicated-human-obesity-is-associated-with-a-specific-cardiac-D0Ih1iKX1W