Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines Claudia B. Fieger * , 1 , Mei-Chuan Huang † , 1 , James R. Van Brocklyn ‡ and Edward J. Goetzl † ,2 Departments of * Anatomy, † Medicine and Microbiology-Immunology, University of California, San Francisco, California, USA; and ‡ Department of Pathology, Ohio State University, Columbus, Ohio, USA 2 Correspondence: University of California, Room UB8B, UC Box 0711, 533 Parnassus at 4th Ave., San Francisco, CA 94143-0711, USA. E-mail: egoetzl@itsa.ucsf.edu <h3>SPECIFIC AIMS</h3> The lysosphingolipid mediator sphingosine 1-phosphate (S1P) affects many functions of different types of cells through a family of five G protein-coupled receptors (GPCRs) designated S1P 1 to S1P 5 . T lymphocytes express predominantly S1P 1 and S1P 4 that are down-regulated by immune activation. S1P 1 transduces signals from S1P that are required for thymocyte emigration, T cell transmigration of lymph nodes, and regulation of T cell chemotaxis in tissues. Alterations in expression of functional S1P 1 receptors by T cells are the major mechanism controlling T cell responses to S1P and were thought to result solely from changes in the balance between cell-surface down-regulation
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Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines
Fieger, Claudia B.; Huang, Mei-Chuan; Van Brocklyn, James R.; Goetzl, Edward J.
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, Volume 19 (13): 1926
Fed of American Socs for Experimental Biology – Nov 1, 2005
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