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Journals The FASEB Journal Volume 18 Issue 10

Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36 AREND BONEN 1 , MICHELLE L. PAROLIN * , GREGORY R. STEINBERG, JORGE CALLES-ESCANDON † , NARENDRA N. TANDON ‡ , JAN F. C. GLATZ § , JOOST J. F. P. LUIKEN § , GEORGE J. F. HEIGENHAUSER || and DAVID J. DYCK Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada; * Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada; † Section of Endocrinology and Metabolism, Wake Forest University School of Medicine & Baptist Medical Center, Winston-Salem North Carolina, USA; ‡ Thrombosis and Vascular Biology Laboratory, Otsuka America Pharmaceutical Inc., Rockville, Maryland, USA; § Department of Molecular Genetics, Maastricht University, Maastricht, The Netherlands; and || Department of Medicine, McMaster University, Hamilton, Ontario, Canada 1 Correspondence: Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario, N1G 2W1, Canada. E-mail: abonen@uogulph.ca <h3>SPECIFIC AIMS</h3> We hypothesized that intramuscular triacylglycerol accumulation in human skeletal muscle was attributable to an increased rate of long chain fatty acid (LCFA) transport into the myocyte as a result of an increase in the

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Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36

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