The T-tubule membrane ATP-operated P2X 4 receptor influences contractility of skeletal muscle Dorianna Sandonà * , Daniela Danieli-Betto † , Elena Germinario † , Donatella Biral ‡ , Tiziana Martinello * , Antonella Lioy * , Elena Tarricone * , Stefano Gastaldello * and Romeo Betto ‡ ,1 * Department of Biomedical and Experimental Sciences and † Department of Human Anatomy and Physiology, University of Padova; and ‡ Laboratory of Muscle Biology and Physiopathology, C.N.R. Neuroscience Institute, Padova, Italy 1 Correspondence: Department of Biomedical Sciences, University of Padova, Padova 35121, Italy. E-mail: betto@bio.unipd.it <h3>SPECIFIC AIM</h3> It has recently been shown that the P2X 4 receptor plays a positive inotropic action in cardiac muscle, where it appears to have an important role in modulating the progression of heart failure. Stimulated by these findings, the aim of this study was to determine the expression, localization, and physiological significance of P2X 4 expression in skeletal muscle. <h3>PRINCIPAL FINDINGS</h3> Extracellular ATP stimulates a large number of biological responses, including neurotransmission in the central and peripheral nervous system, nociception, smooth muscle contraction, immune responses, and platelet aggregation. The nucleotide is actively released from cells via different mechanisms such as exocytosis, transporters, and stretch-activated
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The T-tubule membrane ATP-operated P2X4 receptor influences contractility of skeletal muscle
Sandonà, Dorianna; Danieli-Betto, Daniela; Germinario, Elena; Biral, Donatella; Martinello, Tiziana; Lioy, Antonella; Tarricone, Elena; Gastaldello, Stefano; Betto, Romeo
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, Volume 19 (9): 1184
Fed of American Socs for Experimental Biology – Jul 1, 2005
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