The modulation of caveolin-1 expression controls satellite cell activation during muscle repair Daniela Volonte * , Youhua Liu † and Ferruccio Galbiati * ,1 * Departments of Pharmacology and † Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA 1 Correspondence: Department of Pharmacology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA. E-mail: feg5@pitt.edu <h3>SPECIFIC AIMS</h3> The aim of the present study is to investigate whether caveolin-1, the structural protein component of caveolar membranes, contributes to signaling events that lead to activation of satellite cells during muscle regeneration. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Caveolin-1 is expressed in skeletal muscle satellite cells in vivo</h3> Cross sections of skeletal muscle tissue derived from normal control C57Bl6 mice were stained with an antibody probe specific for caveolin-1. Skeletal muscle sections were costained with anti-caveolin-3 IgGs to detect myofibers. Caveolin-3 was expressed only at the sarcolemma whereas caveolin-1 was selectively expressed in cells surrounding myofibers in vivo (<h3>Fig. 1</h3> ). We performed double staining with caveolin-1 and each of these two markers of satellite cells, CD34 and M-cadherin. Caveolin-1 was expressed in CD34 + and M-cadherin + cells (Fig. 1) , indicating that caveolin-1 is expressed in skeletal muscle satellite cells
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The modulation of caveolin-1 expression controls satellite cell activation during muscle repair
Volonte, Daniela; Liu, Youhua; Galbiati, Ferruccio
Follow The FASEB Journal
, Volume 19 (2): 237
Fed of American Socs for Experimental Biology – Feb 1, 2005
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