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Journals The FASEB Journal Volume 19 Issue 3

The isoprostane 8-iso-PGF 2α suppresses monocyte adhesion to human microvascular endothelial cells via two independent mechanisms Anila Kumar * , Edward Kingdon † and Jill Norman * ,1 * Centre for Nephrology, Division of Medicine, Royal Free and University College Medical School, London, UK; and † Sussex Kidney Unit, Brighton and Sussex University Hospitals Trust, UK 1 Correspondence: Centre for Nephrology, Division of Medicine, Department of Biochemistry and Molecular Biology (2nd floor), Royal Free and University College Medical School, Royal Free Campus, Rowland Hill St., London NW3 2PF, UK. E-mail: j.norman@rfc.ucl.ac.uk <h3>SPECIFIC AIMS</h3> It has been suggested that in addition to being markers of oxidative stress, isoprostanes may have pathogenic functions. The most extensively studied compound is 8-iso-PGF 2α . The aim of the present study was to investigate the actions of 8-iso-PGF 2α on microvascular endothelial cells, focusing specifically on the adhesion of monocytes to the endothelium, an early event in the inflammatory response. <h3>PRINCIPAL FINDINGS</h3> 1. 8-Iso-PGF 2α dose-dependently inhibits monocyte adhesion to human dermal microvascular cells (HMEC) In confluent, quiescent and proliferating HMEC, 8-iso-PGF 2α (10 –12 –10 –5 M) dose-dependently inhibited adhesion of U937 monocytes, with maximal inhibition at 10 –6 M (<h3>Fig. 1</h3>

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The isoprostane 8-iso-PGF2α suppresses monocyte adhesion to human microvascular endothelial cells via two independent mechanisms

Kumar, Anila; Kingdon, Edward; Norman, Jill
The FASEB Journal , Volume 19 (3): 443
Fed of American Socs for Experimental Biology – Mar 1, 2005

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