*Department of Biochemistry and â Department of Pharmacology and Therapeutics, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates; and â¡ Biomedical Sciences Unit, Department of Biological Sciences, Lancaster University, Lancaster, UK ABSTRACT The synucleins are a small, soluble, highly conserved group of neuronal proteins that have been implicated in both neurodegenerative diseases and cancer. The synuclein family consists of -, -, and -synucleins ( -syn). They are a natively unfolded group of proteins that share sequence homologies and structural properties (1, 2). So far, the biological functions of the synucleins are still unclear, but their involvement in neurodegenerative diseases and cancer may provide insights into the pathological processes that result from these two groups of debilitating diseases, and present the possibility to use them as potential targets for early diagnosis and treatment. Recently, elevated levels of -syn proteins have been detected in various types of cancer, especially in advanced stages of the disease. Furthermore, studies to date indicate that overexpression of -syn compromises normal mitotic checkpoint controls, resulting in multinucleation as well as faster cell growth. -Syn has also been shown to promote invasion and metastasis in in vitro assays as
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γ-Synuclein and the progression of cancer
Mushfika Ahmad , Samir Attoub , Maneesh N. Singh , Francis L. Martin , and Omar M. A. El-Agnaf
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, Volume 21 (13): 3419
Fed of American Socs for Experimental Biology – Nov 1, 2007
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