Survival mechanisms in a physiological oxidative stress model Cristina Tomás-Zapico, Beatriz Caballero, Verónica Sierra, Ignacio Vega-Naredo, Óscar Álvarez-García, Delio Tolivia, María Josefa Rodríguez-Colunga and Ana Coto-Montes 1 Departamento de Morfología y Biología Celular, Facultad de Medicina, Universidad de Oviedo, Oviedo, Spain 1 Correspondence: Departamento de Morfología y Biología Celular Facultad de Medicina, C/Julián Clavería s/n, Oviedo 33006, Spain. E-mail: acoto@uniovi.es <h3>SPECIFIC AIMS</h3> The Syrian hamster Harderian gland (HG) has been studied largely with regard to its porphyrin accumulation, the photoreactions where these compounds are implicated and the oxidative stress generated in consequence. Even in porphyrin-dependent oxidative stress conditions, this gland is able to survive without compromising its gland integrity. The aim of this study was to establish a relationship between the high levels of oxidative stress present in the HGs of Syrian hamster and the degenerative changes observed in control HGs. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Invasive processes</h3> Female Syrian hamster HG shows higher cellular damage than males due to their phorphyrin accumulation in the lumen acini. These accumulated porphyrins contribute to a greater extent to the oxidative stress found in the gland. Thus, acini disorganization, described in the female Syrian hamster HG as a release of cells into connective
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Survival mechanisms in a physiological oxidative stress model
Tomás-Zapico, Cristina; Caballero, Beatriz; Sierra, Verónica; Vega-Naredo, Ignacio; Álvarez-García, Óscar; Tolivia, Delio; Rodríguez-Colunga, María Josefa; Coto-Montes, Ana
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, Volume 19 (14): 2066
Fed of American Socs for Experimental Biology – Dec 1, 2005
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