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Somatic DNA damage in interventional cardiologists: a case-control study Maria Grazia Andreassi * ,1 , Angelo Cioppa † , Nicoletta Botto * , Gordana Joksic ‡ , Samantha Manfredi * , Chiara Federici * , Miodrag Ostojic ‡ , Paolo Rubino † and Eugenio Picano * ,† * Institute of Clinical Physiology CNR, Pisa, Italy; † Cardiology Clinic Montevergine, Mercogliano, Italy; and ‡ Institute of Nuclear Sciences, Belgrade, Serbia and Montenegro 1 Correspondence: Institute of Clinical Physiology, CNR, Via Aurelia Sud, Massa 54100, Italy. E-mail: andreas@ifc.cnr.it <h3>SPECIFIC AIMS</h3> Invasive cardiologists working in a busy catheterization laboratories represent, perhaps, the extreme far end (with the highest exposure) of the spectrum of medical radiation workers. The average exposure is 2–3 times higher than that of radiologists and has increased steadily in the past 20 years. With few exceptions, in hospitals with invasive cardiology facilities, badges that exceed the level 1 ALARA (as low as reasonably achievable) limits (<6 mSv/year) are worn by invasive cardiologists. This implies that cardiologists are exposed to significant levels of radiation, which could pose a health hazard if they do not abide by standard safety precautions. Damage to DNA is considered to be the main initiating

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