Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-ß1 Georg H. Waetzig * ,§ , 1 , Philip Rosenstiel * , 1 , Alexander Arlt † , Andreas Till * , Karen Bräutigam * , Heiner Schäfer † , Stefan Rose-John ‡ , Dirk Seegert § , 2 and Stefan Schreiber * , 2 ,3 * Institute of Clinical Molecular Biology and † Laboratory of Molecular Gastroenterology and Hepatology, 1. Department of Medicine, Schleswig-Holstein University Medical Center, Kiel, Germany; ‡ Institute of Biochemistry, Christian-Albrechts-University, Kiel, Germany; and § Conaris Research Institute AG, Kiel, Germany 3 Correspondence: Institute of Clinical Molecular Biology, Schleswig-Holstein University Medical Center, Schittenhelmstrasse 12, Kiel 24105, Germany. E-mail: s.schreiber@mucosa.de <h3>SPECIFIC AIMS</h3> Transmembrane forms of the pivotal proinflammatory cytokine tumor necrosis factor-α (TNF-α) and its two receptors are cleaved by the cell membrane-anchored proteinase TNF-α converting enzyme (TACE), resulting in appreciable serum levels of soluble TNF-α and TNF-α receptors (sTNFR1 and -2). The aims of the present study were to 1) investigate whether sTNFR1 has any signaling functions beyond its known role of neutralizing and buffering TNF-α in the circulation and 2) characterize these novel signaling pathways in
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Soluble tumor necrosis factor (TNF) receptor-1 induces apoptosis via reverse TNF signaling and autocrine transforming growth factor-ß1
Waetzig, Georg H.; Rosenstiel, Philip; Arlt, Alexander; Till, Andreas; Bräutigam, Karen; Schäfer, Heiner; Rose-John, Stefan; Seegert, Dirk; Schreiber, Stefan
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, Volume 19 (1): 91
Fed of American Socs for Experimental Biology – Jan 1, 2005
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