Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration Steven Suchting, Paul Heal, Kiki Tahtis, Lorna M. Stewart and Roy Bicknell 1 Molecular Angiogenesis Laboratory, Cancer Research UK, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK 1 Correspondence: E-mail: roy.bicknell@cancer.org.uk <h3>SPECIFIC AIMS</h3> Roundabout receptors are molecular guidance molecules that function by interaction with Slit proteins to regulate axon guidance, neuronal migration, and leukocyte chemotaxis. We recently isolated a novel roundabout protein, Robo4, which is restricted in expression to endothelial cells in vitro and sites of angiogenesis in vivo. The aim of this study was to use the soluble exrtracellular domain of Robo4 as a probe of function in angiogenesis and endothelial biology. We further aimed to establish whether Robo4, in common with other Robo family members, functions as a Slit receptor. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Soluble Robo4 receptor inhibits in vivo and in vitro angiogenesis</h3> A soluble chimeric receptor (Robo4Fc) comprised of the Robo4 extracellular domain fused to the Fc region of human immunoglobulin was tested in the mouse subcutaneous sponge angiogenesis model. A piece of inert polyether sponge is implanted s.c. in the mouse flank and injected on alternate days with
End of preview. The entire article is 3 pages. To view the full-text, please rent this article to continue.
/lp/fed-of-american-socs-for-experimental-biology/soluble-robo4-receptor-inhibits-in-vivo-angiogenesis-and-endothelial-9ScUY9704U
Welcome to DeepDyve! Rent Premier Research Articles and Save Up to 90%
Soluble Robo4 receptor inhibits in vivo angiogenesis and endothelial cell migration
Suchting, Steven; Heal, Paul; Tahtis, Kiki; Stewart, Lorna M.; Bicknell, Roy
Follow The FASEB Journal
, Volume 19 (1): 121
Fed of American Socs for Experimental Biology – Jan 1, 2005
More Info
More Like This Article
View All dataSource[]=actageo&dataSource[]=aspet&dataSource[]=aaos&dataSource[]=aacc&dataSource[]=aacr&dataSource[]=aea&dataSource[]=aip&dataSource[]=ajnr&dataSource[]=ams&dataSource[]=aps_physical&dataSource[]=appi_book&dataSource[]=appi_journal&dataSource[]=apha&dataSource[]=asip&dataSource[]=asm&dataSource[]=asn&dataSource[]=aspb&dataSource[]=avs&dataSource[]=annual_reviews&dataSource[]=arxiv&dataSource[]=acm&dataSource[]=berghahn&dataSource[]=cabi&dataSource[]=clinical_trials&dataSource[]=dailymed&dataSource[]=degruyter&dataSource[]=du_press&dataSource[]=esa&dataSource[]=eu_press&dataSource[]=elsevier&dataSource[]=emerald&dataSource[]=ejtr&dataSource[]=emea&dataSource[]=epo&dataSource[]=faseb&dataSource[]=gsa&dataSource[]=health_affairs&dataSource[]=hindawi&dataSource[]=imanager&dataSource[]=imedpub&dataSource[]=informa_healthcare&dataSource[]=informs&dataSource[]=iop&dataSource[]=iucr&dataSource[]=iospress&dataSource[]=jbjs&dataSource[]=leftcoast&dataSource[]=lu_press&dataSource[]=mesharpe&dataSource[]=mary_ann_liebert&dataSource[]=medline&dataSource[]=mit_press&dataSource[]=nature&dataSource[]=oxford&dataSource[]=pier_professional&dataSource[]=pnas&dataSource[]=portlandpress&dataSource[]=psyc_articles&dataSource[]=psyc_books&dataSource[]=psyc_critiques&dataSource[]=plos_journal&dataSource[]=pubmed_central&dataSource[]=rsna&dataSource[]=rockefeller&dataSource[]=rcn&dataSource[]=ria&dataSource[]=rsc&dataSource[]=sage&dataSource[]=spie&dataSource[]=springer_journal&dataSource[]=springer&dataSource[]=taylor_francis&dataSource[]=aps&dataSource[]=the_scientist&dataSource[]=uc_press&dataSource[]=uspto_abstract&dataSource[]=wiley&dataSource[]=pct
© 2012 DeepDyve, Inc. All rights reserved.
Terms of Service | Privacy Policy
