Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications 1 CRAIG M. STOLEN 2 , RAMI MADANAT, LUC MARTI * , SEPPO KARI, GENNADY G. YEGUTKIN, HANNU SARIOLA † , ANTONIO ZORZANO * and SIRPA JALKANEN MediCity Research Laboratory, University of Turku and National Public Health Institute, Turku, Finland; * Departament de Bioquímica I Biogia Molecular, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain; and † Developmental Biology Research Program, Institute of Biotechnology, University of Helsinki, Finland 2 Correspondence: MediCity Research Laboratory, University of Turku, Tykistökatu 6A, 20520 Turku, Finland. E-mail: craig.stolen@utu.fi <h3>SPECIFIC AIMS</h3> This work investigates the in vivo significance of elevated semicarbazide-sensitive amine oxidation (SSAO). To investigate the insulin mimicking capacity of SSAO and test its ability to cause and/or exacerbate vascular complications, we overexpressed vascular adhesion protein-1 (VAP-1), an endothelial cell surface and soluble molecule possessing SSAO activity, in transgenic mice, then chronically challenged the mice for 15 months with additional SSAO substrate or an atherogenic diet. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Chronic human VAP-1 overexpression promotes obesity</h3> Despite a decreased caloric intake the transgenic mice had increased weight, body mass index (BMI), and subcutaneous abdominal and epididymal white adipose tissue (WAT) deposits
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Semicarbazide sensitive amine oxidase overexpression has dual consequences: insulin mimicry and diabetes-like complications
STOLEN, CRAIG M.; MADANAT, RAMI; MARTI, LUC; KARI, SEPPO; YEGUTKIN, GENNADY G.; SARIOLA, HANNU; ZORZANO, ANTONIO; JALKANEN, SIRPA
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, Volume 18 (6): 702
Fed of American Socs for Experimental Biology – Apr 1, 2004
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