Selective activation of AMPK-PGC-1α or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation P. J. Atherton * ,† ,‡ , J. Babraj * , K. Smith ‡ , J. Singh † ,1 , M. J. Rennie ‡ and H. Wackerhage * ,‡ * School of Life Sciences, University of Dundee; † Department of Biological Sciences, University of Central Lancashire; and ‡ Clinical Physiology Laboratory, University of Nottingham, UK 1 Correspondence: Department of Biological Sciences, University of Central Lancashire, Preston PR1 2HE, UK. E-mail jsingh3@uclan.ac.uk <h3>SPECIFIC AIMS</h3> Endurance training induces a partial fast-to-slow muscle phenotype transformation and mitochondrial biogenesis, but it usually induces no growth. In contrast, resistance training stimulates muscle growth but has little effect on phenotype. We used 3 h of low-frequency stimulation (LFS) of isolated rat skeletal muscle to mimic endurance training and sixty 3 s bursts of high-frequency stimulation (HFS) to mimic resistance training. The specific aims were to identify signaling events that are activated by either LFS or HFS and that can explain the specific muscle adaptations to such stimulation patterns. <h3>PRINCIPAL FINDINGS</h3> LFS and HFS had specific effects on adaptation markers and on the activation of
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Selective activation of AMPK-PGC-1α or PKB-TSC2-mTOR signaling can explain specific adaptive responses to endurance or resistance training-like electrical muscle stimulation
Atherton, P. J.; Babraj, J.; Smith, K.; Singh, J.; Rennie, M. J.; Wackerhage, H.
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, Volume 19 (7): 786
Fed of American Socs for Experimental Biology – May 1, 2005
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