Retinal dysfunction in patients with chronic Chagas’ disease is associated to anti- Trypanosoma cruzi antibodies that cross-react with rhodopsin Silvia C. Matsumoto * , Vivian Labovsky † , Marcela Roncoroni * , María C. Guida † , Luisa Giménez ‡ , Jorge Mitelman ‡ , Horacio Gori * , Renata Jurgelevicius § , Alejandro Grillo § , Pablo Manfredi § , Mariano J. Levin † and Cristina Paveto † ,1 * Department of Neurology, Hospital Dr. Teodoro Alvarez, Buenos Aires, Argentina; † Instituto de Investigaciones en Ingeniería Genética y Biología Molecular UBA-CONICET, Buenos Aires, Argentina; Departments of ‡ Cardiology and § Ophthalmology, Hospital Dr. Teodoro Alvarez, Buenos Aires, Argentina 1 Correspondence: E-mail: cpaveto@dna.uba.ar <h3>SPECIFIC AIMS</h3> To confirm the existence of a selective dysfunction of retinal rods in patients with chronic Chagas’ heart disease (cChHD), we performed both clinical and electrophysiological studies (i.e., electroretinogram (ERG) and retino fluorescent angiography (RFA)). Serial biochemical experiments were designed to elucidate the molecular mechanism underlying the physiological abnormalities of the visual process. Cross reactivity between anti- Trypanosoma cruzi antibodies and human G-protein-coupled receptors (GPCRs) has been already described. As the photo pigment rhodopsin present in retinal rod cells is a member of this
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Retinal dysfunction in patients with chronic Chagas disease is associated to anti-Trypanosoma cruzi antibodies that cross-react with rhodopsin
Matsumoto, Silvia C.; Labovsky, Vivian; Roncoroni, Marcela; Guida, María C.; Giménez, Luisa; Mitelman, Jorge; Gori, Horacio; Jurgelevicius, Renata; Grillo, Alejandro; Manfredi, Pablo; Levin, Mariano J.; Paveto, Cristina
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, Volume 20 (3): 550
Fed of American Socs for Experimental Biology – Mar 1, 2006
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