Response to "Methyl donors change the germline epigenetic state of the A vy allele" Robert A. Waterland * ,,1 , Michael Travisano † ,‡ and Kajal G. Tahiliani * * Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children’s Nutrition Research Center, Houston, Texas, USA; † Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA; and ‡ Department of Ecology, Evolution and Behavior, University of Minnesota, St. Paul, Minnesota, USA 1 Correspondence: Departments of Pediatrics and Molecular and Human Genetics, Baylor College of Medicine, USDA Children’s Nutrition Research Center, Houston, TX 77030, USA. E-mail: waterland@bcm.edu We appreciate the explanation offered by Cropley et al . for what they perceive is a discrepancy between their results showing an effect of methyl supplementation on the germline epigenetic state of A vy (1) and ours showing that diet-induced hypermethylation at A vy is not inherited transgenerationally (2) . Demonstrating an effect on the germline, however, is not the same as showing transgenerational epigenetic inheritance (3) . Cropley et al . supplemented F0 dams during mid-gestation and assessed effects on coat color in F2 A vy /a offspring. During the period of supplementation the F1
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Response to "Methyl donors change the germline epigenetic state of the Avy allele"
Waterland, Robert A.; Travisano, Michael; Tahiliani, Kajal G.
Follow The FASEB Journal
, Volume 21 (12): 3021
Fed of American Socs for Experimental Biology – Oct 1, 2007
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