Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling Resham Bhattacharya * , Ningling Kang-Decker † , Deborah A. Hughes * , Priyabrata Mukherjee * , Vijay Shah † , Mark A. McNiven * and Debabrata Mukhopadhyay * ,1 * Department of Biochemistry and Molecular Biology, Mayo Clinic Cancer Center, Rochester, Minnesota, USA; and † GI Research Unit, Department of Medicine, Mayo Clinic Foundation, Rochester, Minnesota, USA 1 Correspondence: Department Biochemistry and Molecular Biology, Gugg 1401A, Mayo Clinic Foundation, 200 First St. SW, Rochester, MN 55905, USA. E-mail: mukhopadhyay.debabrata@mayo.edu <h3>SPECIFIC AIMS</h3> KDR is the key receptor that initiates signaling events for VPF/VEGF causing endothelial cell migration, proliferation, and tube formation leading to angiogenesis. Currently, there are at least 80 different drugs in clinical trials targeting KDR. Nonetheless, there is a huge gap in the understanding of mechanisms that regulate compartmentalization and thus signaling of this receptor. Dynamin-2 is a signal-transducing GTPase that has been widely reported to be involved in clathrin- and caveolin-mediated receptor endocytosis. Therefore, the aim of this project was to elucidate the role of dynamin-2 in KDR endocytosis, compartmentalization, and signaling. <h3>PRINCIPAL FINDINGS</h3> <h3>1. KDR is present on the plasma membrane and endosomes as well as
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Regulatory role of dynamin-2 in VEGFR-2/KDR-mediated endothelial signaling
Bhattacharya, Resham; Kang-Decker, Ningling; Hughes, Deborah A.; Mukherjee, Priyabrata; Shah, Vijay; McNiven, Mark A.; Mukhopadhyay, Debabrata
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, Volume 19 (12): 1692
Fed of American Socs for Experimental Biology – Oct 1, 2005
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