Regulation of neovascularization by human neutrophil peptides (α-defensins): a link between inflammation and angiogenesis TRIANTAFYLLOS CHAVAKIS * ,† ,1 , DOUGLAS B. CINES ‡ , JOONG-SUP RHEE * , OLIN D. LIANG * , UWE SCHUBERT * , HANS-PETER HAMMES § , ABD AL-ROOF HIGAZI ‡ , PETER P. NAWROTH † , KLAUS T. PREISSNER * and KHALIL BDEIR ‡ * Institute for Biochemistry, Justus-Liebig-Universität, Giessen, † Department of Internal Medicine I, University of Heidelberg, Heidelberg, Germany; ‡ Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA; and § Department of Internal Medicine, University Clinic Mannheim, Germany 1 Correspondence: Department of Medicine I, University Heidelberg, Bergheimer Strasse 58, Heidelberg D-69115, Germany. Email: triantafyllos.chavakis@med.uni-heidelberg.de <h3>SPECIFIC AIMS</h3> Angiogenesis is a complex biological process that involves several interrelated reactions, such as endothelial cell adhesion, migration, proliferation, and differentiation. It is orchestrated by several growth factors and components of the extracellular matrix, including fibronectin and its receptor, integrin α5ß1. There is emerging evidence that inflammatory cells, particularly neutrophils, regulate endothelial cell functions in angiogenesis. We asked whether human neutrophil peptides (HNP) (also known as α-defensins), abundant in human neutrophils and secreted upon neutrophil activation, can influence angiogenesis. We investigated
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Regulation of neovascularization by human neutrophil peptides (α-defensins): a link between inflammation and angiogenesis
CHAVAKIS, TRIANTAFYLLOS; CINES, DOUGLAS B.; RHEE, JOONG-SUP; LIANG, OLIN D.; SCHUBERT, UWE; HAMMES, HANS-PETER; HIGAZI, ABD AL-ROOF; NAWROTH, PETER P.; PREISSNER, KLAUS T.; BDEIR, KHALIL
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, Volume 18 (11): 1306
Fed of American Socs for Experimental Biology – Aug 1, 2004
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