Chemokines have pleiotropic effects in regulating immunity, angiogenesis, and tumor growth. CXC and CC chemokine families members and their receptors are able to exert a proangiogenic or an antiangiogenic effect in experimental models and in human tumors. In this review article, we have summarized literature data and our studies concerning the angiostatic activity of chemokines. Their angiostatic activity may be a result of a direct effect on the biological functions of endothelial cells and/or an effect on tumor cells inhibiting their capability to stimulate new blood vessel formation. Moreover, chemokines have a pro- and antitumor effect within the tumor microenvironment by regulating immune cell infiltration and its antitumor activities. We have focused our interest on the role of IL-12 and IL-27 in solid and hematological tumors, and we have suggested and discussed their potential use as antiangiogenic agents in the treatment of such tumors. angiogenesis antiangiogenesis multiple myeloma non small cell lung carcinoma Footnotes AKT srine/therenine protein kinase AKT AML acute myeloid leukemia Ang-2 angiopoietin-2 CAM chorioallantoic membrane COX cyclooxygenase ELR Glu-Leu-Arg FGF-2 fibroblast growth factor-2 HIF-1α hypoxia-inducible factor 1 α IFN interferon IL interleukin MM multiple myeloma NSCLC non-small cell lung cancer PROK-2 prokinecitin-2 SCCA squamous cell carcinoma TGF-β transforming growth factor beta TIMP-2 tissue inhibitor of matrix metalloproteinase-2 VEGF vascular endothelial growth factor Received May 11, 2011. Revision received June 21, 2011. Accepted June 23, 2011. © 2011 Society for Leukocyte Biology Facebook Google+ LinkedIn Mendeley Reddit StumbleUpon Technorati Twitter What's this? « Previous | Next Article » Table of Contents This Article Published online before print July 12, 2011 , doi: 10.1189/jlb.0511237 November 2011 Journal of Leukocyte Biology vol. 90 no. 5 875-882 » Abstract Full Text Full Text (PDF) All Versions of this Article: jlb.0511237v1 90/5/875 most recent Classifications Reviews Services Email this article to a colleague Alert me when this article is cited Alert me if a correction is posted Similar articles in this journal Similar articles in PubMed Download to citation manager Citing Articles Load citing article information Google Scholar Articles by Airoldi, I. Articles by Ribatti, D. PubMed PubMed citation Articles by Airoldi, I. Articles by Ribatti, D. Related Content Load related web page information Sharing Email this article to a colleague Facebook Google+ LinkedIn Mendeley Reddit StumbleUpon Technorati Twitter What's this? Current Issue November 2011, 90 (5) From the Cover Editorials: Switching on arginase in M2 macrophages. Editorials: Neutrophil apoptosis: hot on the TRAIL of inflammatory resolution. Spotlight on leading Edge Research: Suppressor of cytokine signaling (SOCS)1 is a key determinant of differential macrophage activation and function. Spotlight on leading Edge Research: TNF-related apoptosis-inducing ligand (TRAIL) regulates inflammatory neutrophil apoptosis and enhances resolution of inflammation. Reviews: Nuocytes: expanding the innate cell repertoire in type-2 immunity. Reviews: Regulation of angiostatic chemokines driven by IL-12 and IL-27 in human tumors. Reviews: Lung dendritic cells at the innate-adaptive immune interface. Technical Advance: Langerhans cells derived from a human cell line in a full-thickness skin equivalent undergo allergen-induced maturation and migration. Alert me to new issues of Journal of Leukocyte Biology About JLB Submit Manuscripts Instructions for Authors Information for Reviewers Editorial Board Editorial Policies Subscriptions Librarian's Resource Advertising Press Room Copyright Permissions Feedback Join SLB SLB Annual Meeting Copyright © 2011 by the Society for Leukocyte Biology Print ISSN: 0741-5400 Online ISSN: 1938-3673 var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); var pageTracker = _gat._getTracker("UA-23108860-1"); pageTracker._trackPageview();

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