Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1 Kotaro Oshio * , Hiroyuki Watanabe * , Yaunlin Song † , A. S. Verkman † and Geoffrey T. Manley * ,1 * Department of Neurosurgery and † Departments of Medicine and Physiology, University of California, San Francisco, California, USA 1 Correspondence: Department of Neurological Surgery, University of California, San Francisco, 1001 Potrero Ave., Bldg. 1, Room 101, San Francisco, CA 94110, USA. E-mail: manley@itsa.ucsf.edu <h3>SPECIFIC AIMS</h3> Aquaporin-1 (AQP1) is a water channel strongly expressed at the ventricular facing surface of choroid plexus epithelium (CPE), where it is thought to play an important role in facilitating water transport across the CPE apical membrane during secretion of cerebrospinal fluid (CSF). The purpose of this study was to define the role of AQP1 in CPE osmotic water permeability, CSF production and absorption, and intracranial pressure (ICP) regulation. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Decreased osmotic water permeability in choroid plexus from AQP1 null mice</h3> Relative CPE cell volume was measured using a spatial filtering light microscopy method. Changing the CSF perfusate osmolality from 300 to 150 mOsm in wild-type mice resulted in a rapid increase in cell volume
End of preview. The entire article is 3 pages. To view the full-text, please rent this article to continue.
/lp/fed-of-american-socs-for-experimental-biology/reduced-cerebrospinal-fluid-production-and-intracranial-pressure-in-g3cBoYaXqQ
Welcome to DeepDyve! Rent Premier Research Articles and Save Up to 90%
Reduced cerebrospinal fluid production and intracranial pressure in mice lacking choroid plexus water channel Aquaporin-1
Oshio, Kotaro; Watanabe, Hiroyuki; Song, Yaunlin; Verkman, A. S.; Manley, Geoffrey T.
Follow The FASEB Journal
, Volume 19 (1): 76
Fed of American Socs for Experimental Biology – Jan 1, 2005
More Info
More Like This Article
View All dataSource[]=actageo&dataSource[]=aspet&dataSource[]=aaos&dataSource[]=aacc&dataSource[]=aacr&dataSource[]=aea&dataSource[]=aip&dataSource[]=ajnr&dataSource[]=ams&dataSource[]=aps_physical&dataSource[]=appi_book&dataSource[]=appi_journal&dataSource[]=apha&dataSource[]=asip&dataSource[]=asm&dataSource[]=asn&dataSource[]=aspb&dataSource[]=avs&dataSource[]=annual_reviews&dataSource[]=arxiv&dataSource[]=acm&dataSource[]=berghahn&dataSource[]=cabi&dataSource[]=clinical_trials&dataSource[]=dailymed&dataSource[]=degruyter&dataSource[]=du_press&dataSource[]=esa&dataSource[]=eu_press&dataSource[]=elsevier&dataSource[]=emerald&dataSource[]=ejtr&dataSource[]=emea&dataSource[]=epo&dataSource[]=faseb&dataSource[]=gsa&dataSource[]=health_affairs&dataSource[]=hindawi&dataSource[]=imanager&dataSource[]=imedpub&dataSource[]=informa_healthcare&dataSource[]=informs&dataSource[]=iop&dataSource[]=iucr&dataSource[]=iospress&dataSource[]=jbjs&dataSource[]=leftcoast&dataSource[]=lu_press&dataSource[]=mesharpe&dataSource[]=mary_ann_liebert&dataSource[]=medline&dataSource[]=mit_press&dataSource[]=nature&dataSource[]=oxford&dataSource[]=pier_professional&dataSource[]=pnas&dataSource[]=portlandpress&dataSource[]=psyc_articles&dataSource[]=psyc_books&dataSource[]=psyc_critiques&dataSource[]=plos_journal&dataSource[]=pubmed_central&dataSource[]=rsna&dataSource[]=rockefeller&dataSource[]=rcn&dataSource[]=ria&dataSource[]=rsc&dataSource[]=sage&dataSource[]=spie&dataSource[]=springer_journal&dataSource[]=springer&dataSource[]=taylor_francis&dataSource[]=aps&dataSource[]=the_scientist&dataSource[]=uc_press&dataSource[]=uspto_abstract&dataSource[]=wiley&dataSource[]=pct
© 2012 DeepDyve, Inc. All rights reserved.
Terms of Service | Privacy Policy
