Presenilin 2 regulates the systolic function of heart by modulating Ca 2+ signaling Toshihiro Takeda * , Michio Asahi † , Osamu Yamaguchi * , Shungo Hikoso * , Hiroyuki Nakayama * , Yoichiro Kusakari ‡ , Makoto Kawai ‡ , Kenichi Hongo ‡ , Yoshiharu Higuchi * , Kazunori Kashiwase * , Tetsuya Watanabe * , Masayuki Taniike * , Atsuko Nakai * , Kazuhiko Nishida * , Satoshi Kurihara ‡ , Dorit B. Donoviel § , Alan Bernstein § , Taisuke Tomita ¶ , Takeshi Iwatsubo ¶ , Masatsugu Hori * and Kinya Otsu * ,1 * Department of Cardiovascular Medicine and † Department of Biochemistry, Osaka University Graduate School of Medicine, Suita, Osaka; ‡ Department of Physiology (II), The Jikei University School of Medicine, Tokyo, Japan; § Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada; and ¶ Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, Tokyo, Japan 1 Correspondence: Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan. E-mail: kotsu@medone.med.osaka-u.ac.jp <h3>SPECIFIC AIMS</h3> Mutations in presenilin 2 (PS2) genes account for early-onset Alzheimer’s disease, and PS2 is ubiquitously expressed in various tissues
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Presenilin 2 regulates the systolic function of heart by modulating Ca2+ signaling
Takeda, Toshihiro; Asahi, Michio; Yamaguchi, Osamu; Hikoso, Shungo; Nakayama, Hiroyuki; Kusakari, Yoichiro; Kawai, Makoto; Hongo, Kenichi; Higuchi, Yoshiharu; Kashiwase, Kazunori; Watanabe, Tetsuya; Taniike, Masayuki; Nakai, Atsuko; Nishida, Kazuhiko; Kurihara, Satoshi; Donoviel, Dorit B.; Bernstein, Alan; Tomita, Taisuke; Iwatsubo, Takeshi; Hori, Masatsugu; Otsu, Kinya
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, Volume 19 (14): 2069
Fed of American Socs for Experimental Biology – Dec 1, 2005
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