Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation 1 TIFFANY J. MELLOTT * , CHRISTINA L. WILLIAMS † , WARREN H. MECK † and JAN KRZYSZTOF BLUSZTAJN * * Department of Pathology and Laboratory Medicine, Boston University School of Medicine, Boston, Massachusetts, USA; and † Department of Psychological and Brain Sciences, Duke University, Durham, North Carolina, USA 2 Correspondence: Boston University School of Medicine, 715 Albany St., L804, Boston, MA 02118, USA. E-mail jbluszta@bu.edu <h3>SPECIFIC AIMS</h3> Choline is an essential nutrient for animals and humans. Previous studies showed that supplementing maternal diet with choline during the second half of gestation in rats permanently enhances memory performance of the adult offspring. This study investigated the hypothesis that the activity of the hippocampal mitogen-activated protein kinase (MAPK)/cAMP-response element binding protein (CREB) pathway mediates the enhanced cognitive performance observed in prenatally choline-supplemented rats. We examined the ability of juvenile rats to use relational cues in a water maze task and the level of phosphorylation of both MAPK and CREB in hippocampal slices in response to a depolarizing concentration of potassium or stimulation by glutamate or N-methyl-D-aspartate (NMDA) in prenatally choline-supplemented, choline-deficient, and control rats. <h3>PRINCIPAL FINDINGS</h3> <h3>1.
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Prenatal choline supplementation advances hippocampal development and enhances MAPK and CREB activation
MELLOTT, TIFFANY J.; WILLIAMS, CHRISTINA L.; MECK, WARREN H.; BLUSZTAJN, JAN KRZYSZTOF
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, Volume 18 (3): 545
Fed of American Socs for Experimental Biology – Mar 1, 2004
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