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Journals The FASEB Journal Volume 18 Issue 11

Pleiotrophin mRNA is highly expressed in neural stem (progenitor) cells of mouse ventral mesencephalon and the product promotes production of dopaminergic neurons from embryonic stem cell-derived nestin-positive cells CHA-GYUN JUNG * ,1 , HIDEKI HIDA * , KENSUKE NAKAHIRA † , KAZUHIRO IKENAKA ‡ , HYE-JUNG KIM * and HITOO NISHINO * ,§ * Department of Neuro-Physiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; † Department of Physiology, Saitama Medical School, Saitama, Japan; ‡ Laboratory of Neural Information and § Divison of Learning and Memory Research, National Institute for Physiological Sciences, Okazaki National Research Institutes, Okazaki, Japan 1 Correspondence: Department of Neuro-Physiology and Brain Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-Ku, Nagoya 467-8601, Japan. E-mail: jung@med.nagoya-cu.ac.jp <h3>SPECIFIC AIM</h3> To understand the mechanism of neural differentiation, especially with dopaminergic (DAergic) neurons, the aim of the present study was to create a gene file of neural stem (progenitor) cells derived from mouse (E12.5) ventral mesencephalon using serial analysis of gene expression (SAGE). Among 15,815 tags investigated, pleiotrophin (PTN) mRNA was highly expressed in these cells. Since PTN affects cell migration, repair, neurite outgrowth, and differentiation of neural development, we

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Pleiotrophin mRNA is highly expressed in neural stem (progenitor) cells of mouse ventral mesencephalon and the product promotes production of dopaminergic neurons from embryonic stem cell-derived nestin-positive cells

JUNG, CHA-GYUN; HIDA, HIDEKI; NAKAHIRA, KENSUKE; IKENAKA, KAZUHIRO; KIM, HYE-JUNG; NISHINO, HITOO
The FASEB Journal , Volume 18 (11): 1237
Fed of American Socs for Experimental Biology – Aug 1, 2004

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