Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth 1 XIAO-MING LIU, SYLVIA V. REYNA, DIANA ENSENAT, KELLY J. PEYTON, HONG WANG, ANDREW I. SCHAFER and WILLIAM DURANTE * ,2 Michael E. DeBakey VA Medical Center and Departments of Medicine and * Pharmacology, Baylor College of Medicine, Houston, Texas, USA 2 Correspondence: VA Medical Center, Bldg. 109, Room 130, 2002 Holcome Blvd., Houston, TX 77030, USA. E-mail: wdurante@bcm.tmc.edu <h3>SPECIFIC AIM</h3> System L amino acid transport mediates the sodium-independent uptake of nonpolar branched-chain or aromatic neutral amino acids and is the major route by which mammalian cells take up nutritionally essential amino acids from extracellular fluids. Genes encoding the proteins responsible for system L amino acid transport have been cloned and designated LAT1 and LAT2. Both proteins require covalent association with the heavy chain of 4F2 cell surface antigen (4F2hc) for their functional expression in the plasma membrane. Since essential amino acids are required for cell growth, the present study examined the effect of the vascular smooth muscle cell (SMC) mitogen, platelet-derived growth factor (PDGF), on system L-amino acid transport. <h3>PRINCIPAL FINDINGS</h3> <h3>1. Vascular SMC express system L amino acid transport activity</h3> We
End of preview. The entire article is 3 pages. To view the full-text, please rent this article to continue.
/lp/fed-of-american-socs-for-experimental-biology/platelet-derived-growth-factor-stimulates-lat1-gene-expression-in-0czOrr1PKx
Welcome to DeepDyve! Rent Premier Research Articles and Save Up to 90%
Platelet-derived growth factor stimulates LAT1 gene expression in vascular smooth muscle: role in cell growth
LIU, XIAO-MING; REYNA, SYLVIA V.; ENSENAT, DIANA; PEYTON, KELLY J.; WANG, HONG; SCHAFER, ANDREW I.; DURANTE, WILLIAM
Follow The FASEB Journal
, Volume 18 (6): 768
Fed of American Socs for Experimental Biology – Apr 1, 2004
More Info
More Like This Article
View All dataSource[]=actageo&dataSource[]=aspet&dataSource[]=aaos&dataSource[]=aacc&dataSource[]=aacr&dataSource[]=aea&dataSource[]=aip&dataSource[]=ajnr&dataSource[]=ams&dataSource[]=aps_physical&dataSource[]=appi_book&dataSource[]=appi_journal&dataSource[]=apha&dataSource[]=asip&dataSource[]=asm&dataSource[]=asn&dataSource[]=aspb&dataSource[]=avs&dataSource[]=annual_reviews&dataSource[]=arxiv&dataSource[]=acm&dataSource[]=berghahn&dataSource[]=cabi&dataSource[]=clinical_trials&dataSource[]=dailymed&dataSource[]=degruyter&dataSource[]=du_press&dataSource[]=esa&dataSource[]=eu_press&dataSource[]=elsevier&dataSource[]=emerald&dataSource[]=ejtr&dataSource[]=emea&dataSource[]=epo&dataSource[]=faseb&dataSource[]=gsa&dataSource[]=health_affairs&dataSource[]=hindawi&dataSource[]=imanager&dataSource[]=imedpub&dataSource[]=informa_healthcare&dataSource[]=informs&dataSource[]=iop&dataSource[]=iucr&dataSource[]=iospress&dataSource[]=jbjs&dataSource[]=leftcoast&dataSource[]=lu_press&dataSource[]=mesharpe&dataSource[]=mary_ann_liebert&dataSource[]=medline&dataSource[]=mit_press&dataSource[]=nature&dataSource[]=oxford&dataSource[]=pier_professional&dataSource[]=pnas&dataSource[]=portlandpress&dataSource[]=psyc_articles&dataSource[]=psyc_books&dataSource[]=psyc_critiques&dataSource[]=plos_journal&dataSource[]=pubmed_central&dataSource[]=rsna&dataSource[]=rockefeller&dataSource[]=rcn&dataSource[]=ria&dataSource[]=rsc&dataSource[]=sage&dataSource[]=spie&dataSource[]=springer_journal&dataSource[]=springer&dataSource[]=taylor_francis&dataSource[]=aps&dataSource[]=the_scientist&dataSource[]=uc_press&dataSource[]=uspto_abstract&dataSource[]=wiley&dataSource[]=pct
© 2012 DeepDyve, Inc. All rights reserved.
Terms of Service | Privacy Policy
