Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice Catherine Desrumaux # , Pierre-Yves Risold † , Henri Schroeder * , Valérie Deckert # , David Masson # , Anne Athias # , Hélène Laplanche # , Naig Le Guern # , Denis Blache # , Xian-Cheng Jiang ‡ , Alan R. Tall § , Didier Desor * and Laurent Lagrost # ,1 # Laboratoire de Biochimie des Lipoprotéines, INSERM, Dijon, France; † Laboratoire d’Histologie, Faculté de Médecine et de Pharmacie, Besançon, France; * Laboratoire de Neurosciences Comportementales, Faculté des Sciences, Vandoeuvre les Nancy, France; ‡ State University of New York, Downstate Medical Center, Brooklyn, New York, USA; § Department of Medicine, Columbia University, New York, New York, USA 1 Correspondence: INSERM U498-Faculté de Médecine, 7, Bd Jeanne d’Arc BP 87900, 21079 DIJON Cedex. E-mail: Laurent.Lagrost@u-bourgogne.fr <h3>SPECIFIC AIMS</h3> Chronic oxidative stress and aging are major risk factors of neurodegenerative disorders, and the use of antioxidants constitutes a promising strategy in the prevention of brain damage. Although plasma phospholipid transfer protein (PLTP) promotes the exchange of vitamin E (an essential lipid-soluble antioxidant) between lipoproteins and cells, it is unknown whether PLTP functions as
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Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice
Desrumaux, Catherine; Risold, Pierre-Yves; Schroeder, Henri; Deckert, Valérie; Masson, David; Athias, Anne; Laplanche, Hélène; Le Guern, Naig; Blache, Denis; Jiang, Xian-Cheng; Tall, Alan R.; Desor, Didier; Lagrost, Laurent
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, Volume 19 (2): 296
Fed of American Socs for Experimental Biology – Feb 1, 2005
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